Pipeline

Developing novel biologics for autoimmune diseases

Jade’s focus is to develop transformational, disease-modifying therapies targeting autoimmune diseases. The company’s lead candidate, JADE101, is a potentially best-in-class antibody designed to block the cytokine APRIL (A PRoliferation Inducing Ligand) protein. JADE101 is anticipated to enter the clinic in the second half of 2025, with interim biomarker-rich data expected in the first half of 2026. Jade’s pipeline also includes a second development candidate, JADE201, and an undisclosed antibody discovery program, JADE-003, both currently in preclinical development.

Program
Candidate
Discovery
IND-Enabling
Planned Clinical FIH
Planned Interim FIH Data
Potential Indications

JADE101 is a potential best-in-class monoclonal antibody designed to block the APRIL (A PRoliferation Inducing Ligand) protein, which plays a key role in the development of IgA nephropathy (IgAN), a chronic kidney disease resulting from inflammation and damage that can impair kidney function over time. By targeting the underlying pathogenesis of IgAN, JADE101 is designed to reduce IgA levels, lower protein levels in the urine (a key marker of kidney damage), and preserve long-term kidney function.

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MOA: UndisclosedJADE-002
JADE201
1H26
Multiple systemic AI diseases
MOA: UndisclosedJADE-003
1H27
Undisclosed
Candidate JADE101
Planned Clinical FIH 2H25
Planned Healthy Volunteer Data 1H26
Potential Indications IgAN

JADE101 is a potential best-in-class monoclonal antibody designed to block the APRIL (A PRoliferation Inducing Ligand) protein, which plays a key role in the development of IgA nephropathy (IgAN), a chronic kidney disease resulting from inflammation and damage that can impair kidney function over time. By targeting the underlying pathogenesis of IgAN, JADE101 is designed to reduce IgA levels, lower protein levels in the urine (a key marker of kidney damage), and preserve long-term kidney function.

Learn more
Candidate JADE201
Planned Clinical FIH 1H26
Planned Healthy Volunteer Data
Potential Indications Multiple systemic AI diseases
Candidate
Planned Clinical FIH 1H27
Planned Healthy Volunteer Data
Potential Indications Undisclosed